Curr Biol：分散注意力可有效大大降低疼痛感

昨日，刊载在的国际著名周报Cell的子刊Current Biology上的一篇分析报告宣称，能用人格干扰（分心）的方法可以使得咳嗽加重，然而这种咳嗽缓解加重的震荡并不展现出在头部。这项分析挖掘出是基于使用高分辨率的骨髓机能性磁共振成像系统设计（fMRI系统设计），对人们由于湿度惹来的咳嗽水平进行分析，分析推断出，人格干扰确实可以在中都枢咳嗽检视早期抑制咳嗽频谱的中都叶。来自科隆-埃彭多夫所大学的大学的科学界Christian Sprenger对此，这种现象并不仅仅是一种人格现象，而是一种广为人知的神经的系统，可以降很低从脊髓上升至神经元高级周边的咳嗽频谱。

这种震荡限于到了内源性的衍生物，这种物质产生自神经元，在加重咳嗽的过程中都最不可忽视不可忽视角色。分析人员让自发性分别完成一个简单或者一个很难的记忆性勤务，需要他们记住信件的楔形文字细节，同时给自发性肩膀上施以湿度。进行很难勤务的自发性变得心烦意乱时，他们会无法忍受较小的咳嗽，通过fMRI系统设计反映出这些自发性的脊髓周边活性变得非常很低，fMRI通常是用来测定神经元活性的扭转。

Sprenger和他的朋友然后减法了实验，这次他们给予自发性一种药剂-钠洛酮（抗休克的难得药剂，可以阻拦吗啡的震荡）或者普通的盐水流向，得出，相比只流向普通盐水的自发性，使用吗啡拮抗剂的自发性由于注意力分散，惹来的咳嗽缓解降很低了40%，因此指出内源性的最不可忽视不可忽视起着。

科学界的挖掘出推断出了人格过程可以熟悉地扭转人们的咳嗽经历，并且对于外科也有关键的象征意义。科学界对此，我们的分析挖掘出给咳嗽疾病病患提供了认知行径病患的方法。（生物谷：T.Shen编译）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.